Calpains are a family of calcium‐dependent thiol‐proteases which are proposed to be involved in many physiological processes as well as pathological conditions. Calpains are likely to be involved in processing of numerous enzymes and cytoskeletal components, thereby linking their activity to a variety of intracellular events. Although widely studied, the precise mechanism(s) involved in calpain activation and activity in vivo remain poorly understood. Initial studies suggested that calpain exists primarily as an inactive proenzyme that required autolytic cleavage for activation. It (...) was also hypothesized that calpain associated with membrane phospholipids, serving to increase calcium sensitivity, facilitating autolytic conversion and thus activating the enzyme. These hypotheses, however, have not been universally accepted and there is increasing evidence that intact, non‐autolyzed calpain is the physiologically active calpain form. (shrink)

The challenge that confronts corporate decision-makers in connection with global labor conditions is often in identifying the standardsby which they should govern themselves. In an effort to provide greater direction in the face of possible global cultural conflicts, ethicistsThomas Donaldson and Thomas Dunfee draw on social contract theory to develop a method for identifying basic human rights: Integrated Social Contract Theory (ISCT). In this paper, we apply ISCT to the challenge of global labor standards, attempting to identify labor rights that (...) could serve as guides for corporations producing or outsourcing outside of their home country. In addition to identifying areas of universal agreement, we also examine whether ISCT is, in fact, a sufficient basis for determining worker rights; we seek to define the parameters of the “sweatshop” problem; we include the application and results of our ISCT analysis as applied to labor standards: the global labor rights hypernorms; and conclude that ISCT is sufficient only for rights that are universal. We also discuss whether market-driven decisions can identify the boundaries of labor rights, or at least assure that market outcomes are compatible with maintaining labor rights, in order to respond to the shortcomings of ISCT. We conclude with some comments on directions of analysis for labor rights determination. (shrink)

Popper and Eccles present two different notions of Interactionism. Popper's arguments arise out of the traditional philosophical debate, whereas Eccles' arguments arise out of a mixture of neurophysiology and personal belief. Popper's three-world ontology is the philosophical foundation of both their positions. However, it is precisely against the background of the three Worlds that the considerable differences between their positions are apparent. Despite these defects, Interactionism is a productive notion since it does not place the Self beyond experimental investigation. Indeed, (...) both Popper and Eccles have made implicit suggestions as to experimental procedure which might contribute to the investigation of the Self. (shrink)

Popper and Eccles present two different notions of Interactionism. Popper's arguments arise out of the traditional philosophical debate, whereas Eccles' arguments arise out of a mixture of neurophysiology and personal belief. Popper's three-world ontology is the philosophical foundation of both their positions. However, it is precisely against the background of the three Worlds that the considerable differences between their positions are apparent. Despite these defects, Interactionism is a productive notion since it does not place the Self beyond experimental investigation. Indeed, (...) both Popper and Eccles have made implicit suggestions as to experimental procedure which might contribute to the investigation of the Self. (shrink)

We describe new results in parametrized complexity theory. In particular, we prove a number of concrete hardness results for W[P], the top level of the hardness hierarchy introduced by Downey and Fellows in a series of earlier papers. We also study the parametrized complexity of analogues of PSPACE via certain natural problems concerning k-move games. Finally, we examine several aspects of the structural complexity of W [P] and related classes. For instance, we show that W[P] can be characterized in terms (...) of the DTIME ) and NP. (shrink)

Cenzer, D., R. Downey, C. Jockusch and R.A. Shore, Countable thin Π01 classes, Annals of Pure and Applied Logic 59 79–139. A Π01 class P {0, 1}ω is thin if every Π01 subclass of P is the intersection of P with some clopen set. Countable thin Π01 classes are constructed having arbitrary recursive Cantor- Bendixson rank. A thin Π01 class P is constructed with a unique nonisolated point A and furthermore A is of degree 0’. It is shown that no (...) set of degree ≥0” can be a member of any thin Π01 class. An r.e. degree d is constructed such that no set of degree d can be a member of any thin Π01 class. It is also shown that between any two distinct comparable r.e. degrees, there is a degree that contains a set which is of rank one in some thin Π01 class. It is shown that no maximal set can have rank one in any Π01 class, while there exist maximal sets of rank 2. The connection between Π01 classes, propositional theories and recursive Boolean algebras is explored, producing several corollaries to the results on Π01 classes. For example, call a recursive Boolean algebra thin if it has no proper nonprincipal recursive ideals. Then no thin recursive Boolean algebra can have a maximal ideal of degree ≥0”. (shrink)

We study completely decomposable torsion-free abelian groups of the form $\mathcal{G}_S := \oplus_{n \in S} \mathbb{Q}_{p_n}$ for sets $S \subseteq \omega$. We show that $\mathcal{G}_S$has a decidable copy if and only if S is $\Sigma^0_2$and has a computable copy if and only if S is $\Sigma^0_3$.

We develop a theory of LOGSPACE structures and apply it to construct a number of examples of Abelian Groups which have LOGSPACE presentations. We show that all computable torsion Abelian groups have LOGSPACE presentations and we show that the groups ${\mathbb {Z}, Z(p^{\infty})}$ , and the additive group of the rationals have LOGSPACE presentations over a standard universe such as the tally representation and the binary representation of the natural numbers. We also study the effective categoricity of such groups. For (...) example, we give conditions are given under which two isomorphic LOGSPACE structures will have a linear space isomorphism. (shrink)

This work contributes to the program of studying effective versions of “almost-everywhere” theorems in analysis and ergodic theory via algorithmic randomness. Consider the setting of Cantor space {0,1}N with the uniform measure and the usual shift. We determine the level of randomness needed for a point so that multiple recurrence in the sense of Furstenberg into effectively closed sets P of positive measure holds for iterations starting at the point. This means that for each k∈N there is an n such (...) that n,2n,…,kn shifts of the point all end up in P. We consider multiple recurrence into closed sets that possess various degrees of effectiveness: clopen, Π10 with computable measure, and Π10. The notions of Kurtz, Schnorr, and Martin-Löf randomness, respectively, turn out to be sufficient. We obtain similar results for multiple recurrence with respect to the k commuting shift operators on {0,1}Nk. (shrink)

Many natural computational problems have input consisting of two or more parts, one of which may be considered a parameter. For example, there are many problems for which the input consists of a graph and a positive integer. A number of results are presented concerning parameterized problems that can be solved in complexity classes below P, given a single word of advice for each parameter value. Different ways in which the word of advice can be employed are considered, and it (...) is shown that the class FPT of tractable parameterized problems has interesting and natural internal structure. (shrink)

Isaiah Berlin, 1909-1997 John Edward Christopher Hill, 1912-2003 Rodney Howard Hilton, 1916-2002 Morris Keith Hopkins, 1934-2004 Thomas Peter Ruffell Laslett, 1915-2001 Geoffrey Marshall, 1929-2003 John Smith Roskell, 1913-1998 Isaac Schapera, 1905-2003 Judah Benzion Segal, 1912-2003 John Cyril Smith, 1922-2003 Richard Arthur Wollheim, 1923-2003.

The relationship between humanity and the soil is an increasingly important topic in social theory. However, conceptualisations of the soil developed by anticolonial thinkers at the high point of the movement for self-determination between the 1940s and the 1970s have remained largely ignored. This is a shame, not least because theorists like Eric Williams, Walter Rodney, Suzanne Césaire and Amílcar Cabral were concerned with the soil. Building on recent work on human-soil relations and decolonial ecology, we argue that these (...) four thinkers conceptualised the connection between soil, empire, and anticolonial revolt. Williams and Rodney ground understanding of soil degradation in global relations of economic power, while Césaire and Cabral reconceptualise postcolonial nationhood in terms of the mutability and diversity of the soil. The article concludes by suggesting that these two anticolonial counterpoints, global connectivity and more-than-human identification, anticipate and deepen contemporary attempts to decolonise ecological thinking. (shrink)

Rsenha da obra: GUTTMANN, Julius. 4 Filosofia do Judaismo — A História da Filosofia Judaica desde os Tempos Bíblicos até Franz Rosenzweig, São Paulo: Perspectiva, 2003, 480 p., Trad. de J. Guinsburg, Apresentação do Tradutor e Prefácio à edição Brasileira de Roberto Romano, Posfácio de Fritz Bamberger, ISBN 852730530-5.

Background Noninvasive prenatal testing (NIPT) designed to screen for fetal genetic conditions, is increasingly being implemented as a part of routine prenatal care screening in the United States (US). However, these advances in reproductive genetic technology necessitate empirical research on the ethical and social implications of NIPT among populations underrepresented in genetic research, particularly Black women with sickle cell disease (SCD).Methods Forty (N = 40) semi-structured interviews were conducted virtually with Black women in the US (19 participants with SCD; 21 (...) participants without SCD) from June 2021 to January 2022. We employed a qualitative approach to examine the study participants’ perceptions of the potential advancement of NIPT for screening SCD in the fetus. Data were analyzed using NVivo 12 qualitative software.Results The themes revealed the complexities involving the intersectional lived experiences of SCD, prenatal care, lack of synergy among health providers, and NIPT decision-making. The results further revealed that even when Black women have shared commonalities in their lived experiences while navigating SCD and motherhood, their perceptions of NIPT screening technologies are divergent.Conclusion Expanding the ethical discourse on the social implications of NIPT is critical to fully elucidate how Black women perceive NIPT’s utility, particularly as NIPT advances to screen for SCD in the fetus. Neglecting to include Black women with genetic conditions in empirical studies on NIPT may contribute to ongoing health inequities and limit and constrain reproductive choices among Black women with and without SCD. (shrink)

The paper deals with the question of whether poverty as such violates the dignity of persons. It is argued that it does. This is, it is argued, not due to a lack of basic goods, nor to the fact that poverty prevents persons from enjoying the rights they have, particularly the right to bodily integrity. Poverty does violate dignity, so it is argued, insofar as poor people are dependent on others in a degrading way.

In what follows I propose to bring out certain methodological properties of projects of modelling the tacit realm that bear on the kinds of modelling done in connection with scientific cognition by computer as well as by ethnomethodological sociologists, both of whom must make some claims about the tacit in the course of their efforts to model cognition. The same issues, I will suggest, bear on the project of a cognitive psychology of science as well.

Awareness of, and respect for differences of gender, race, religion, language, and culture have liberated many oppressed groups from the hegemony of white, Western males. However, respect for previously denigrated collective identities should not be allowed to confine individuals to identities constructed around one main component used for political mobilisation, or to identities that depend on a priority of properties that are not optional, like race, gender, and language. In this article I want to sketch an approach for accommodating different (...) kinds of identity within a multicultural constitutional democracy. From a vantage point provided by a definition and explanation of personal identity, I want to show how people define, construct and change their personal identities to make themselves into unique individuals. Next I show how democratic political institutions and the personal identities of individuals reciprocally influence one another. In the final section I sketch ways in which diverse personal identities ought to be accommodated in multicultural constitutional democracies. The conclusion is that a society which gives its members the liberty, space, and opportunity to freely construct their own identities might avoid the formation of closed groups committed exclusively to their own sectional interests. (shrink)

The purpose of this study is to examine the relationship between the corporate social performance of an organization and three variables: the size of the organization, the financial performance of the organization, and the environmental performance of the organization. By empirically testing data from 1987 to 1992, the results of the study show that a firm's corporate social performance is indeed impacted by the size of the firm, the level of profitability of the firm, and the amount of pollution emissions (...) released by the firm. (shrink)

This book explains, in simple but accurate terms, how orthodox quantum mechanics works. The author, a distinguished theoretical physicist, shows how this theory, realistically interpreted, assigns an important role to our conscious free choices. Stapp claims that mainstream biology and neuroscience, despite nearly a century of quantum physics, still stick essentially to failed classical precepts in which mental intentions have no effect upon our bodily actions. He shows how quantum mechanics provides a rational basis for a better understanding of this (...) connection, even allowing an explanation of certain phenomena currently held to be "paranormal". These ideas have major implications for our understanding of ourselves and our mental processes, and thus also for the meaningfulness of our lives. (shrink)

It is fortunate for my purposes that English has the two words ‘almighty’ and ‘omnipotent’, and that apart from any stipulation by me the words have rather different associations and suggestions. ‘Almighty’ is the familiar word that comes in the creeds of the Church; ‘omnipotent’ is at home rather in formal theological discussions and controversies, e.g. about miracles and about the problem of evil. ‘Almighty’ derives by way of Latin ‘omnipotens’ from the Greek word ‘pantokratōr’; and both this Greek word, (...) like the more classical ‘pankratēs’, and ‘almighty’ itself suggest God's having power over all things. On the other hand the English word ‘omnipotent’ would ordinarily be taken to imply ability to do everything; the Latin word ‘omnipotens’ also predominantly has this meaning in Scholastic writers, even though in origin it is a Latinization of ‘pantocratōr’. So there already is a tendency to distinguish the two words; and in this paper I shall make the distinction a strict one. I shall use the word ‘almighty’ to express God's power over all things, and I shall take ‘omnipotence’ to mean ability to do everything. (shrink)

This fourth and final volume of the monumental commentary on Wittgenstein's _Philosophical Investigations_ covers pp 428-693 of the book. Like the previous volumes, it consists of philosophical essays and exegesis.

I offer an alternative account of the relationship of Hobbesian geometry to natural philosophy by arguing that mixed mathematics provided Hobbes with a model for thinking about it. In mixed mathematics, one may borrow causal principles from one science and use them in another science without there being a deductive relationship between those two sciences. Natural philosophy for Hobbes is mixed because an explanation may combine observations from experience (the ‘that’) with causal principles from geometry (the ‘why’). My argument shows (...) that Hobbesian natural philosophy relies upon suppositions that bodies plausibly behave according to these borrowed causal principles from geometry, acknowledging that bodies in the world may not actually behave this way. First, I consider Hobbes's relation to Aristotelian mixed mathematics and to Isaac Barrow's broadening of mixed mathematics in Mathematical Lectures (1683). I show that for Hobbes maker's knowledge from geometry provides the ‘why’ in mixed-mathematical explanations. Next, I examine two explanations from De corpore Part IV: (1) the explanation of sense in De corpore 25.1-2; and (2) the explanation of the swelling of parts of the body when they become warm in De corpore 27.3. In both explanations, I show Hobbes borrowing and citing geometrical principles and mixing these principles with appeals to experience. (shrink)